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Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic

《医学前沿（英文）》 doi: 10.1007/s11684-023-1022-x

摘要： The treatment of PML/RARA+ acute promyelocytic leukemia (APL) with all-trans-retinoic acid and arsenic trioxide (ATRA/ATO) has been recognized as a model for translational medicine research. Though an altered microenvironment is a general cancer hallmark, how APL blasts shape their plasma composition is poorly understood. Here, we reported a cross-sectional correlation network to interpret multilayered datasets on clinical parameters, proteomes, and metabolomes of paired plasma samples from patients with APL before or after ATRA/ATO induction therapy. Our study revealed the two prominent features of the APL plasma, suggesting a possible involvement of APL blasts in modulating plasma composition. One was characterized by altered secretory protein and metabolite profiles correlating with heightened proliferation and energy consumption in APL blasts, and the other featured APL plasma-enriched proteins or enzymes catalyzing plasma-altered metabolites that were potential trans-regulatory targets of PML/RARA. Furthermore, results indicated heightened interferon-gamma signaling characterizing a tumor-suppressing function of the immune system at the first hematological complete remission stage, which likely resulted from therapy-induced cell death or senescence and ensuing supraphysiological levels of intracellular proteins. Overall, our work sheds new light on the pathophysiology and treatment of APL and provides an information-rich reference data cohort for the exploratory and translational study of leukemia microenvironment.

关键词： acute promyelocytic leukemia     plasma proteomics     plasma metabolomics     cross-sectional correlation network     pathogenesis     treatment    

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Prevalence and determinations of physical inactivity among public hospital employees in Shanghai, China: a cross-sectional

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《医学前沿（英文）》 2015年 第9卷 第1期   页码 100-107 doi: 10.1007/s11684-014-0372-9

摘要：

This study aims to explore the prevalence and determinations of physical inactivity among hospital employees in Shanghai, China. A cross-sectional study of 4612 employees aged 19 to 68 years was conducted through stratified cluster sampling from different classes of Shanghai hospitals in 2011. The total physical activity was evaluated using the metabolic equivalent according to the Global Physical Activity Questionnaire. Among the participants, 38.5%, 32.3%, and 64.6% of the employees are inactive at work, commuting, and taking leisure time, respectively. Up to 41.8% of the men and 37.8% of the women (P = 0.012) are physically inactive. When the age and educational level are adjusted, male doctors and medical technicians show a higher percentage of physical inactivity than male workers in logistics (P = 0.001). Among females, employees who are working in second- and third-class hospitals show a higher proportion of physical inactivity than those who are working in community health care centers. Logistic regression analyses show that the odds ratios (ORs) of leisure-time physical inactivity associated with the intensity of physical activity at work are 2.259, 2.897, and 4.266 for men (P<0.001) and 2.456, 3.259, and 3.587 for women (P<0.001), respectively. The time during commuting activities is significantly associated with leisure-time physical inactivity in either sex (OR= 2.116 for men and 2.173 for women, P<0.001). Hospital employees, particularly doctors and medical technicians, show a higher proportion of physical inactivity than other inhabitants in Shanghai. The time and intensity of activity at work and commuting are associated with leisure-time activities.

关键词： prevalence     determination     employee     public hospital     cross-sectional study     physical inactivity    

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Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetesmellitus: a cross-sectional cohort study

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

《医学前沿（英文）》 2020年 第14卷 第5期   页码 642-650 doi: 10.1007/s11684-019-0719-3

摘要： This study aimed to investigate the correlation between serum miR-154-5p and urinary albumin to creatinine ratio (UACR) in patients with type 2 diabetes mellitus (T2DM) and the association with biomarkers of inflammation and fibrosis in diabetic kidney disease (DKD). A total of 390 patients with T2DM were divided into three groups: normal albuminuria (UACR<30 mg/g, =136, NA), microalbuminuria (UACR at 30–300 mg/g, =132, MA), and clinical albuminuria (UACR>300 mg/g, =122, CA). Circulating miR-154-5p, inflammatory (C-reactive protein (CRP); erythrocyte sedimentation rate (ESR); and tumor necrosis factor-α (TNF-α) and fibrotic markers (vascular endothelial growth factor (VEGF); transforming growth factor-β1 (TGF-β1); and fibronectin (FN)), and other biochemical indicators were assessed via real-time PCR, enzyme-linked immunosorbent assay, and chemiluminescence assay in patients with T2DM and 138 control subjects (NC). UACR, miR-154-5p, glycated hemoglobin (HbA1c), serum creatinine (sCr), blood urea nitrogen (BUN), ESR, CRP, VEGF, TNF-α, TGF-β1, and FN were significantly higher and the estimated glomerular filtration rate (eGFR) was significantly lower in NA, MA, and CA groups than in NC subjects ( <0.05). Elevated levels of UACR and miR-154-5p were directly correlated with HbA1c, sCr, BUN, ESR, CRP, VEGF, TNF-α, TGF-β1, and FN and negatively correlated with eGFR ( <0.05). miR-154-5p, HbA1c, sCr, BUN, eGFR, ESR, CRP, VEGF, TNF-α, TGF-β1, and FN were important factors affecting UACR. These findings indicated that elevated serum miR-154-5p is significantly correlated with high UACR in patients with T2DM and may offer a novel reference for the early diagnosis of DKD.

关键词： type 2 diabetes mellitus     diabetic kidney disease     miR-154-5p     urinary albumin to creatinine ratio    

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overweight prevalence and its association with undiagnosed hypertension in Shanghai population, China: a cross-sectional

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《医学前沿（英文）》 2012年 第6卷 第3期   页码 322-328 doi: 10.1007/s11684-012-0204-8

摘要：

The aim of this study was to determine the prevalence of overweight and obese subjects in the Shanghai population of China and its association with undiagnosed hypertension, by taking age, gender and place of residence (urban or suburban) into account. A cross-sectional population-based survey was conducted in 2007. The sample included 13 359 participants aged 15–69 years. Weight, height, and blood pressure were recorded, and information about gender, age and place of residence was obtained. Overweight and obesity prevalence were calculated by the body mass index (BMI) definition recommended by Working Group on Obesity in China (normal weight, 18.5–23.9 kg/m2; overweight, 24–27.9 kg/m2; obesity,≥28 kg/m2). Undiagnosed hypertension was defined by China criteria in accord with that of WHO-ISH (subjects with systolic pressure≥140 mmHg, and/or diastolic pressure≥90 mmHg). Multiple logistic regression analyses were used to assess the association of overweight or obesity with undiagnosed hypertension by adjusting for age, gender and place of residence. The overall overweight, obesity, and undiagnosed hypertension prevalence were 27.6% (95% CI: 26.8–28.4), 6.6% (95% CI: 6.2–7.0), and 15.5% (95% CI: 14.9–16.1), respectively. Compared to normal weight subjects, the odds ratios (OR) for subjects who were overweight and had hypertension was 2.33 (95% CI: 2.10–2.59); that for obesity and hypertension was 4.27 (95% CI: 3.66–4.99). These data suggest that overweight and obesity prevalence and their association with undiagnosed hypertension are high in our study population.

关键词： overweight     obesity     undiagnosed hypertension     prevalence     association    

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Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in

《医学前沿（英文）》 2022年 第16卷 第6期   页码 969-974 doi: 10.1007/s11684-021-0912-z

摘要： Malaria is highly prevalent in Nigeria and accounts for approximately 40% of global malaria mortality. However, most reports on severe malaria in Nigeria are from hospital-based studies without accurate information from communities; thus, malaria-related deaths in the community are left untracked. This study aimed to describe the prevalence and pattern of severe malaria in a community in Northwestern Nigeria. A cross-sectional study was conducted among 2–10-year-old children in Sokoto, in August and December 2016, to determine the endemicity of malaria based on Plasmodium falciparum prevalence rate (PfPR2-10) and to describe the disease pattern. Severe malaria was diagnosed according to the World Health Organisation criteria. Data were described using Stata version 15. The prevalence of non-anaemia severe malaria was higher than expected (2.6%), considering the endemicity pattern which was mesoendemic based on a PfPR2-10 of 34.8%. The mean age of children with severe malaria was 3.73 years, and the male–female ratio was 2:1. However, 54.0% of the patients had hyperparasitaemia. A relatively high prevalence of non-anaemia severe malaria was found in Wamakko. This finding suggests the need to identify and treat cases in the community using modifications of current strategies, particularly seasonal malaria chemoprophylaxis.

关键词： severe malaria     nigeria     malaria mortality     PfPR2-10     intermediate malaria transmission    

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terminating the Bacillus Calmette--Guérin booster vaccination: subgroup analysis of a population-based cross-sectional

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《医学前沿（英文）》 2017年 第11卷 第4期   页码 528-535 doi: 10.1007/s11684-017-0573-0

摘要：

The prevalence of tuberculosis infection among adolescents born after terminating the Bacillus Calmette–Guérin (BCG) booster vaccination in China was estimated using tuberculin skin testing (TST) and QuantiFERON-TB Gold assay (QFT) to investigate the influence of neonatal BCG vaccination on the performance of TST. Data analysis was conducted for 2831 eligible participants aged 5–15 years from the baseline survey of a population-based multi-center prospective study. The prevalence rates of TST (induration≥10 mm) and QFT positivity were 9.3% (264/2827) and 2.5% (71/2831), respectively. The rate of QFT indeterminate result was 2.2% (62/2831). The overall agreement between TST and QFT was low (concordance= 88.0%; κ coefficient= 0.125). Only TST was positively associated with BCG vaccination with an adjusted odds ratio of 1.71 [95% confidence interval, 1.26–2.31]. A history of close contact with patients of active TB was significantly associated with positivity for TST and QFT. Our results suggested that BCG neonatal vaccination still affects TST performance, and a two-step approach might be considered for TB infection testing among adolescents in China.

关键词： tuberculin skin test     interferon-γ release assays     adolescent     agreement    

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Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic

《医学前沿（英文）》 2022年 第16卷 第6期   页码 984-990 doi: 10.1007/s11684-022-0930-5

摘要： Nonpharmaceutical interventions (NPIs) have been commonly deployed to prevent and control the spread of the coronavirus disease 2019 (COVID-19), resulting in a worldwide decline in influenza prevalence. However, the influenza risk in China warrants cautious assessment. We conducted a cross-sectional, sero-epidemiological study in Shandong Province, Northern China in mid-2021. Hemagglutination inhibition was performed to test antibodies against four influenza vaccine strains. A combination of descriptive and meta-analyses was adopted to compare the seroprevalence of influenza antibodies before and during the COVID-19 pandemic. The overall seroprevalence values against A/H1N1pdm09, A/H3N2, B/Victoria, and B/Yamagata were 17.8% (95% CI 16.2%–19.5%), 23.5% (95% CI 21.7%–25.4%), 7.6% (95% CI 6.6%–8.7%), and 15.0 (95% CI 13.5%–16.5%), respectively, in the study period. The overall vaccination rate was extremely low (2.6%). Our results revealed that antibody titers in vaccinated participants were significantly higher than those in unvaccinated individuals (P < 0.001). Notably, the meta-analysis showed that antibodies against A/H1N1pdm09 and A/H3N2 were significantly low in adults after the COVID-19 pandemic ( P < 0.01). Increasing vaccination rates and maintaining NPIs are recommended to prevent an elevated influenza risk in China.

关键词： influenza virus     seroprevalence     antibody     COVID-19     cross-sectional study    

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An automated arc spray tooling system for rapid die-making of large-sized automobile body panels

HE Zhong-yun, LU Bing-heng, WANG Yi-qing, HONG Jun, TANG Yi-ping

《机械工程前沿（英文）》 2006年 第1卷 第2期   页码 209-214 doi: 10.1007/s11465-006-0012-4

摘要： A creative robot wrist consisting of link mechanisms and a novel robot motion control method based on the cross-sectional vector contours of an STL-formatted model was proposed. By using the wrist and the control method, an industrial robot with five degrees of freedom for rapid tooling using metal arc spraying and electric brush plating techniques was developed. The wrist of the robot including a specially designed link mechanism can maintain the position of the spraying point on the surface of the master pattern whatever the orientation of the gun. Therefore, the kinematic nonlinear coupling between the position mechanism and orientation mechanism in a traditional robot can be avoided. The only input of the control system is the STL-formatted 3D CAD model of the pattern. Without the need of any manual programming, the metal arc spraying and brush plating (if necessary) processes can be performed automatically and efficiently after receiving the 3D CAD data of the pattern. Using this robot system in new car development and trial production, the cost and lead-time can be reduced substantially as compared with the conventional tool making method.

关键词： industrial     position mechanism     orientation     surface     cross-sectional    

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国际对比研究计划——面向地震预测的跨断层测量

何满潮, 隋麒儒, 陶志刚​​​​​​​

《工程（英文）》 2023年 第31卷 第12期   页码 15-18 doi: 10.1016/j.eng.2023.03.016

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Deep convolutional tree-inspired network: a decision-tree-structured neural network for hierarchical

《机械工程前沿（英文）》 2021年 第16卷 第4期   页码 814-828 doi: 10.1007/s11465-021-0650-6

摘要： The fault diagnosis of bearings is crucial in ensuring the reliability of rotating machinery. Deep neural networks have provided unprecedented opportunities to condition monitoring from a new perspective due to the powerful ability in learning fault-related knowledge. However, the inexplicability and low generalization ability of fault diagnosis models still bar them from the application. To address this issue, this paper explores a decision-tree-structured neural network, that is, the deep convolutional tree-inspired network (DCTN), for the hierarchical fault diagnosis of bearings. The proposed model effectively integrates the advantages of convolutional neural network (CNN) and decision tree methods by rebuilding the output decision layer of CNN according to the hierarchical structural characteristics of the decision tree, which is by no means a simple combination of the two models. The proposed DCTN model has unique advantages in 1) the hierarchical structure that can support more accuracy and comprehensive fault diagnosis, 2) the better interpretability of the model output with hierarchical decision making, and 3) more powerful generalization capabilities for the samples across fault severities. The multiclass fault diagnosis case and cross-severity fault diagnosis case are executed on a multicondition aeronautical bearing test rig. Experimental results can fully demonstrate the feasibility and superiority of the proposed method.

关键词： bearing     cross-severity fault diagnosis     hierarchical fault diagnosis     convolutional neural network     decision tree    

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Virtual network embedding based on real-time topological attributes

Jian DING,Tao HUANG,Jiang LIU,Yun-jie LIU

《信息与电子工程前沿（英文）》 2015年 第16卷 第2期   页码 109-118 doi: 10.1631/FITEE.1400147

摘要： As a great challenge of network virtualization, virtual network embedding/mapping is increasingly important. It aims to successfully and efficiently assign the nodes and links of a virtual network (VN) onto a shared substrate network. The problem has been proved to be NP-hard and some heuristic algorithms have been proposed. However, most of the algorithms use only the local information of a node, such as CPU capacity and bandwidth, to determine how to map a VN, without considering the topological attributes which may pose significant impact on the performance of the embedding. In this paper, a new embedding algorithm is proposed based on real-time topological attributes. The concept of betweenness centrality in graph theory is borrowed to sort the nodes of VNs, and the nodes of the substrate network are sorted according to the correlation properties between the former selected and unselected nodes. In this way, node mapping and link mapping can be well coupled. A simulator is built to evaluate the performance of the proposed virtual network embedding (VNE) algorithm. The results show that the new algorithm significantly increases the revenue/cost (R/C) ratio and acceptance ratio as well as reduces the runtime.

关键词： Virtual network embedding (VNE)     Real-time topological attributes     Betweenness centrality     Correlation properties     Network virtualization    

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Preparation and properties of gel membrane containing porous PVDF-HFP matrix and cross-linked PEG for

ZHANG Mei, CUI Zhenyu, ZHU Baoku, HAN Gaige, XU Youyi, ZHANG Aiqing

《化学科学与工程前沿（英文）》 2008年 第2卷 第1期   页码 89-94 doi: 10.1007/s11705-008-0011-6

摘要： Lithium ion conducting membranes are the key materials for lithium batteries. The lithium ion conducting gel polymer electrolyte membrane (Li-GPEM) based on porous poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) matrix and cross-linked PEG network is prepared by a typical phase inversion process. By immersing the porous PVDF-HFP membrane in liquid electrolyte containing poly(ethylene glycol) diacrylate (PEGDA) and an initiator to absorb the liquid electrolyte at 25°C, and then thermally cross-linking at 60°C, the Li-GPEM is fabricated successfully. The measurements on its weight loss, mechanical and electrochemical properties reveal that the obtained Li-GPEM has better overall performance than the liquid and blend gel systems used as conductive media in lithium batteries. The ionic conductivity of the fabricated Li-GPEM can reach as high as 2.25 × 10 S/cm at 25°C.

关键词： ethylene     PEGDA     inversion     network     initiator    

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心电图信号的频域分析

涂承媛,曾衍钧,李树信

《中国工程科学》 2002年 第4卷 第12期   页码 66-70

摘要：

提出了一种简便有效的、由心电图（ECG）曲线提取QRS-T复合波的新方法，从而获得P波（当房颤未发生时）或f波（当房颤时）；利用功率谱、自相关、互相关等信号处理技术，对它进行了处理和分析，特别是，比较了未房颤时和发生房颤时的相关信息的显著差别。

关键词： 心电图（ECG）     QRS-T复合波     P波     房颤波（f波）     频数直方图     功率谱     自相关     互相关    

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Sectional model test study on vortex-excited resonance of vehicle-bridge system of Shanghai Bridge over

Li ZHOU, Yaojun GE

《结构与土木工程前沿（英文）》 2009年 第3卷 第1期   页码 67-72 doi: 10.1007/s11709-009-0007-4

摘要： It is necessary to study how vehicles influence the vortex-excited resonance of vehicle-bridge systems, because lock-in wind speed is low and vortex-excited resonance is sensitive to any change in the main girder sections. Based on the Shanghai Bridge over the Yangtse River, the vortex-excited resonance of a 1∶60 scale sectional model was tested in a TJ-1wind tunnel, with or without vehicles at the attack angle of 0°, +3 and -3°, respectively. The conversion relationships between the resonant amplitudes of the sectional model and that of the prototype bridge were also established by mode shape correction. The result indicates that: 1) for the bridge with vehicles, the vertical vortex-excited resonance is accompanied by torsion vibration with the same frequency, and vice versa, 2) the amplitude of vortex-excited resonance of the bridge with vehicles is much larger than that of the bridge without vehicles, and 3) the lock-in wind speed of the vortex-excited resonance becomes smaller due to the disturbance of vehicles. It is obvious that vehicles bring about changes in the aerodynamic shape of the main girder. Therefore, the influence of vehicles on vortex-excited resonance performance of vehicle-bridge systems, in terms of both amplitude and mode, should not be ignored.

关键词： vehicle-bridge system     sectional mode     vortex-excited resonance     wind tunnel test     mode shape correction    

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无线传感器网络中基于尺度的协同中继跨层QoS路由算法

徐楠,孙亚民,于继明,王华

《中国工程科学》 2011年 第13卷 第3期   页码 45-49

摘要：

提出了一种基于尺度的协同中继自主转发跨层QoS路由算法(MCRICQR)。节点根据能量、信道、拥塞以及与汇点的距离等综合因素形成一个选择度量，度量最大的节点根据自己所处状态自主选择直接转发、中继转发以及跃进转发数据包。仿真结果表明，该算法能根据网络状况及时转发数据，提高网络可靠性，对网络负载进行均衡，提高网络吞吐量和能量效率，从而延长网络寿命，保障了无线传感器网络的QoS需求。

关键词： 服务质量     跨层设计     协同中继     自主转发     无线传感器网络    

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标题 作者 时间 类型 操作

Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic

期刊论文

Prevalence and determinations of physical inactivity among public hospital employees in Shanghai, China: a cross-sectional

null

期刊论文

Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetesmellitus: a cross-sectional cohort study

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

期刊论文

overweight prevalence and its association with undiagnosed hypertension in Shanghai population, China: a cross-sectional

null

期刊论文

Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in

期刊论文

terminating the Bacillus Calmette--Guérin booster vaccination: subgroup analysis of a population-based cross-sectional

null

期刊论文

Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic

期刊论文

An automated arc spray tooling system for rapid die-making of large-sized automobile body panels

HE Zhong-yun, LU Bing-heng, WANG Yi-qing, HONG Jun, TANG Yi-ping

期刊论文

国际对比研究计划——面向地震预测的跨断层测量

何满潮, 隋麒儒, 陶志刚​​​​​​​

期刊论文

Deep convolutional tree-inspired network: a decision-tree-structured neural network for hierarchical

期刊论文

Virtual network embedding based on real-time topological attributes

Jian DING,Tao HUANG,Jiang LIU,Yun-jie LIU

期刊论文

Preparation and properties of gel membrane containing porous PVDF-HFP matrix and cross-linked PEG for

ZHANG Mei, CUI Zhenyu, ZHU Baoku, HAN Gaige, XU Youyi, ZHANG Aiqing

期刊论文

心电图信号的频域分析

涂承媛,曾衍钧,李树信

期刊论文

Sectional model test study on vortex-excited resonance of vehicle-bridge system of Shanghai Bridge over

Li ZHOU, Yaojun GE

期刊论文

无线传感器网络中基于尺度的协同中继跨层QoS路由算法

徐楠,孙亚民,于继明,王华

期刊论文